2008 - 2012
The use of cyclic-di-GMP, a novel immunotherapeutic and antibacterial molecule in chickens
Principal Investigator: Moussa Diarra, Agriculture and Agri-Food Canada and François Malouin, Université de Sherbrooke
Collaborators: Brian Talbot, Université de Sherbrooke
BackgroundThe objective of this project is to demonstrate the usefulness of cyclic-di-GMP, a novel immunotherapeutic molecule, for the prevention of infections by microbial pathogens in chickens. These molecules have been shown to protect mice from bacterial challenge (S. aureus) and elicit varied immune system responses. Human immature dendritic cells in culture also show responses to the presence of c-di-GMP. The responses demonstrated in these and other studies suggest that c-di-GMP is a novel immunostimulant that could be used to protect poultry from bacterial infections and as a new adjuvant for vaccines against poultry pathogens.
Specific objectives are to demonstrate the ability of c-di-GMP to enhance host immunity and to provide proof of concept for their use in chicken production to replace antibiotherapies and antibiotic-based growth promoters. The project will look at the effect of c-di-GMP on the immune response to IBDV vaccination in broiler chickens, on gut microflora and emergence of resistant bacteria, and on the control of Clostridium perfringens in broiler chickens.
Funding$223,954 ($60,002 CPRC, $163,952 AAFC)