2017 - 2020
An inexpensive plant-derived multi-component vaccine for poultry coccidiosis and necrotic enteritis
Principal Investigator: Joenel Alcantara, University of Calgary
Co-investigator: Faizal Careem, University of Calgary
Status: In progress
ObjectiveDevelop a plant-derived multi-competent vaccine against coccidiosis and necrotic enteritis.
BackgroundThe Canadian poultry industry faces flock loss due to infection by pathological agents resulting in production losses, increased mortality, reduced welfare of birds, and increased contamination of poultry products for human consumption. Enteric diseases are among the most devastating diseases and include coccidiosis and necrotic enteritis (NE). The current trend is to reduce the use of antibiotic and anti-parasitic drugs due to the emergence of drug-resistant strains and consumer concerns about these drugs entering the food chain. Vaccination provides a practical method to control these enteric diseases. The majority of licensed coccidiosis vaccines consist of live, attenuated organisms. However, this type of vaccine has inherent problems as Eimeria species do not propagate well in vitro and cell cultures are prone to contamination. The primary objective of this project is to develop a plant-derived multi-competent vaccine against coccidiosis and necrotic enteritis to counter the challenges associated with present approach to vaccine propagation.
Funding$112,500 (CPRC $40,000, NSERC $55,000, Alberta Chicken Producers $17,500 ($7,500 in-kind)