ObjectiveTo prepare vitamin B5 functionalized cationic amphipathic peptides of different hydrophobicity and cationic character by solid phase peptide synthesis and study their biocompatibility and antimicrobial properties in gram positive and gram negative bacteria in vitro.
BackgroundSalmonella enteriditis is a major cause of Salmonellosis infection in laying hens and may pose a threat to human health, due to consumption of contaminated eggs.1 Salmonellosis infection in chicken can occur due to poor husbandry conditions, stress, and mucosal damage. Salmonella localizes in intestinal and reproductive tract of laying hens, and is linked to the production of contaminated eggs and poultry meat for consumers. The proposal to develop biologically safe synthetic antimicrobials, which can overcome S. enteriditis infection by direct killing of pathogen, is an attractive alternative to achieve clean and organic poultry products. Supplementation of avian diet with probiotics or organic acids indirectly boosts bird immune system against deadly pathogen. The researcher presents a direct method to control the growth of pathogen in laying hens.
Funding$107,050 (AAFC/CPRC/EFC $77,050*, Biovectra $30,000 (in-kind))
*This research is part of the 2018-2023 Poultry Science Cluster which is supported by AAFC as part of the Canadian Agricultural Partnership, a federal-provincial-territorial initiative.