Results


***FSQ111

2018 - 2023

Rationale-based mitigation of relevant Campylobacter jejuni strains within the broiler production continuum

Principal Investigator: Douglas Inglis, Agriculture and Agri-Food Canada
Status: In progress

Objective

The researcher proposes to employ a multi-faceted approach to mitigate relevant Campylobacter jejuni (Cj) strains within the broiler production system. Specifically, to: (1) identify Cj strains associated with poultry production and processing operations in Canada, including the identification of Clinically Relevant (CR) Cj strains; (2) determine important reservoirs and mechanisms by which Cj strains enter broiler operational housing units, and are transmitted throughout the continuum; (3) experimentally ascertain the mechanisms involved in infection and colonization of birds by Cj strains, and their transmission within flocks; (4) elucidate key phenotypic characteristics of CR Cj strains (e.g. that permit them to competitively colonize the Gastro-Intestinal Tract (GIT) of chickens, and persist extra-intestinally);  (5) develop effective diagnostics for CR Cj for use by the sector; (6) explore effective mitigation of CR Cj within abattoirs and on farm; and (7) protect Intellectual Property (IP), and develop and implement a Knowledge Translation and Commercialization (KTC) plan to optimize benefits to producers.

Background

There is currently little information on the establishment and transmission of Clostridium jejuni throughout the poultry production continuum in Canada, and particularly, that of CR subtypes. The researcher contends that the lack of success in controlling this bacterium to date is due in large part to the incomplete understanding of Cj strain dynamics (i.e. CR subtypes). Understanding the subtypes that colonize poultry and go on to infect people, identifying their reservoirs and investigating their transmission dynamics throughout the production continuum is critical to developing tools and mitigation strategies.

Funding

$583,591 (AAFC/CPRC $558,591*, Alberta Chicken Producers $25,000 (In-Kind))

*This research is part of the 2018-2023 Poultry Science Cluster which is supported by AAFC as part of the Canadian Agricultural Partnership, a federal-provincial-territorial initiative.


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