2018 - 2023

A comparative and subtractive reverse vaccinology approach to develop an in ovo vaccine against Clostridium perfringens

Principal Investigator: Martine Boulianne, University of Montreal
Co-investigator: Joshua Gong, Agriculture and Agri-Food Canada
Status: In progress


With the current pressure to reduce antibiotic use and/or produce antibiotic-free chickens, there is a dire need for new tool to better control NE. Comparative reverse vaccinology is the most efficient method to identify vaccine candidates as well an excellent way to better understand the pathogenesis of NE. The main Objectif is to develop an efficacious vaccine, but given the paucity of current knowledge in the area of C. perfringens and NE pathogenesis and control, the research will yield fundamental new knowledge in these areas and, in the longer term, will provide a basis for immune intervention strategies for the control of NE in chickens, which is prevalent in Canada and globally causing significant economic losses to broiler, broiler breeders and laying hens housed in aviaries.


$738,650 (AAFC/CPRC $459,450*, Fondation Claire et Jean-Pierre L├ęger to Chair of poultry research $150,000, NSERC $29,200, Annual Endowment return, Chair in Poultry Research $100,000)

*This research is part of the 2018-2023 Poultry Science Cluster which is supported by AAFC as part of the Canadian Agricultural Partnership, a federal-provincial-territorial initiative.

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