2018 - 2023

Non-antibiotic control of bacterial infections in poultry

Principal Investigator: Arshud Dar, University of Saskatchewan
Status: In progress


The main objective of these studies is to develop and characterize non-antibiotics based in ovo and post hatch effective, safe and economical strategies for control of bacterial infections in poultry.
  • To optimize proven in ovo effective non-antibiotic agents for control of Yolk Sac Infection and early chick mortality (ECM) in chickens.
  • To characterize newly identified non-antibiotics reagents or combination of proven effective non-antibiotics reagents for treatment and reduction in colonization of foodborne pathogens including Salmonella, Campylobacter and Clostridium in chickens.
  • Development of a in ovo and post hatch effective repertoire of non- antibiotic anti infection agents as alternative to antibiotics in chicken production
  • Development of experimental infection model of necrotic enteritis and its prevention through in ovo administration of non-antibiotic reagents as a step towards complete replacement of antibiotics in poultry feed.
  • Evaluation of synergy or antagonism of in ovo administered new non antibiotic reagents with in ovo Marek‚Äôs disease vaccination


In Europe, bacterial infections including yolk sac infection (YSI) and colibacillosis (prime cause of early chick mortalities), asymptomatic colonization of Salmonella and Campylobacter (major food safety and public health issues), clinical and subclinical Clostridial infection have been reported as the leading economic and public health issues following with drawl of antibiotics in poultry production (Gadde et al., 2017b; Seal et al., 2013). Importantly, prevention of these infections without use of antibiotics is challenging for researchers and the poultry farming community around the globe. Notably, this experimental yolk sac infection model used for evaluation of these immune stimulants was developed in last poultry cluster project II.


$400,200 (AAFC/CPRC $320,700*, Saskatchewan Agriculture Development Fund $59,500, Chicken Farmers of Saskatchewan $20,000)

*This research is part of the 2018-2023 Poultry Science Cluster which is supported by AAFC as part of the Canadian Agricultural Partnership, a federal-provincial-territorial initiative.

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